Nutraceuticals：3(3) (2023)

The Marine Factor 3,5-Dihydroxy-4-methoxybenzyl Alcohol Represses Adipogenesis in Mouse 3T3-L1 Adipocytes In Vitro: Regulating Diverse Signaling Pathways

Masayoshi Yamaguchi,Kenji Yoshiike, Hideaki Watanabe and Mitsugu Watanabe

Curr Mol Med：(2023)

The Marine Factor 3,5-dihydroxy-4-methoxybenzyl Alcohol Suppresses Cell Growth, Inflammatory Cytokine Production, and NF-κB Signaling-enhanced Osteoclastogenesis in In Vitro Mouse Macrophages RAW264.7 Cells

Masayoshi Yamaguchi, Kenji Yoshiike, Hideaki Watanabe, Mitsugu Watanabe

International Journal of Molecular Sciences：24(12) (2023)

A Pacific Oyster-Derived Antioxidant, DHMBA, Protects Renal Tubular HK-2 Cells against Oxidative Stress via Reduction of Mitochondrial ROS Production and Fragmentation

Hsin-Jung Ho,Natsumi Aoki ,Yi-Jou Wu ,Ming-Chen Gao ,Karin Sekine ,Toshihiro Sakurai ,Hitoshi Chiba ,Hideaki Watanabe ,Mitsugu Watanabe Shu-Ping Hui

Anticancer Drugs：33(5) (2022)

The marine factor 3,5-dihydroxy-4-methoxybenzyl alcohol suppresses growth, migration and invasion and stimulates death of metastatic human prostate cancer cells: targeting diverse signaling processes

Masayoshi Yamaguchi, Kenji Yosiike, Hideaki Watanabe, Mitsugu Watanabe

The Journal of Japan Mibyou Association：27(1) (2021)

The effects of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA)- containing fraction isolated from soft tissue of the Pacific oyster (Crassostrea gigas) on sleep electroencephalogram in stressed rats

Mitsugu Watanabe, Katsuya Kuroki, Kenji Yoshiike and Narumi Aramaki

BIO Clinica：36(1) (2021)

Antioxidant in the brain and stress-relieving effects of an antioxidant (DHMBA)

Mitsugu Watanabe

Jpn Pharmacol Ther：48(11) (2020)

Effect of intake of jelly compounded with 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA)- containing supernatant extracted from soft tissue of the Pacific oyster (Crassostrea gigas) on perception of stress and sleep quality in healthy working men and women.

－Randomized, Double-blind, Placebo-controlled, Comparative Study－

Mitsugu Watanabe, Koki Tanio, Mitsuhisa Takahashi, Narumi Aramaki, Humitoshi Horie, Jiro Saito

CMC Publishing Co.,Ltd. Development of Functional Foods for Anti-Fatigue, Anti-Stress, and Improving Sleep Quality：187-197 (2020)

Fatigue-mitigating and stress-mitigating properties of fractions containing the novel antioxidant 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), isolated from soft tissue of the Pacific oyster (Crassostrea Gigas), due to their antioxidant capacity.

Mitsugu Watanabe

The Journal of Japan Mibyou Association： 26(1) (2020)

Antioxidant and stress-mitigating properties of the antioxidant 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) from soft tissue of the Pacific oyster (Crassostrea gigas) in intracerebral oxidative stress-caused hypothalamo-hypophysealadrenal facilitated mouse

Mitsugu Watanabe, Takayuki Watanabe,

Jpn Pharmacol Ther : 46(3) , 2018

Effect of intake of jelly compounded with 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA)-containing supernatant extracted from soft tissue of the Pacific oyster (Crassostrea gigas) on fatigue in healthy middle-aged men and women. －Randdomized, Double-blind, Placebo-controlled, Comparative Study－

Mitsugu Watanabe, Emiko Miki, Er Jin Eio, Mitsuhisa Takahashi, Riko Fukuda.

Journal of Functional Foods: 35, 2017

Comparison of chemical structures and cytoprotection abilities between direct and antioxidants.

Joko S., Watanabe M., Fuda H., Takeda S., Furukawa T., Hui S.P., Shrestha R., and Chiba H.

Jpn Pharmacol Ther : 45(2), 2017

Effects of intake of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA)-containing oyster extract drink on the status of stress, fatigue, and sleep: a randdomized, double-blind, placebo-controlled, parallel-group study.

Watanabe M, Miki E, Watanabe T, Katagiri M, Fukuda R, Urade Y.

Jpn Pharmacol Ther : 45(1), 2017

Antioxidant and stress-mitigating properties of the phenoloic antioxidant 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), isolated from soft tissue of the Pacific oyster (Crassostrea Gigas), in a mouse model of oxidative stress.

Watanabe M, Miki E, Urade Y.

Journal of Functional Foods: 20, 2016

Oyster extracts attenuate pathologial changes in non-alcoholic steatohepatitis (NASH) mouse model.

Watanabe M., Fuda H., Okabe H., Joko S., Miura Y., Hui S.P., Yimin, Hamaoka N., Miki E., and Chiba H.

Food Chemistry： vol.176, 2015

Anti-apoptitic effects of novel phenolic antioxidant isolated from the Pacific Oyster (Crassostrea Gigas) on cultured human hepatocytes under oxidative stress.

Fuda H., Watanabe M., Hui S.P., Joko S., Okabe H., Jin S., Takeda S., Miki E., Watanabe T., and Chiba H.

284-292,CMC (2013)

Feeding trial to evaluate usefulness of functional food materials in humans

Mitsugu WATANABE

Food Chemistry： vol.134 issue4, 2012

A phenolic antioxidant from the Pacific oyster (Crassostrea Gigas) inhibits oxidation of cultured human hepatocytes mediated by diphenyl-1-Pyrenylphosphine

Mitsugu WATANABE, Hirotoshi FUDA, Shigeki JIN, Toshihiro SAKURAI, Shu-Ping HUI, Seiji TAKEDA, Takayuki WATANABE, Takao KOIKE, Hitoshi CHIBA

Journal of Agricultural and Food Chemistry： vol.60　 No.3, 2012

Isolation and characterization of a phenolic antioxidant from the Pacific Oyster (Crassostrea Gigas)

Mitsugu WATANABE, Hirotoshi FUDA, Shigeki JIN, Toshihiro SAKURAI, Futaba OHKAWA, Shu-Ping HUI, Seiji TAKEDA, Takayuki WATANABE, Takao KOIKE, and Hitoshi CHIBA

Japanese Journal of Health Promotion： Vol.14 No.1,　2012

Effect of the food containing oyster extract on stress, fatigue, quality of sleep and quality of life in working persons

Mitsugu WATANABE, Tetsuro YAMAMOTO, Chang Hua HUANG, Hisayoshi OKAMURA, Akira TSUDA

Neurochemistry International ：Vol.56 No.3　2010

Susceptibility to stress in young rats after 2-week zinc deprivation

Mitsugu WATANABE, Haruna TAMANO, Toshinori KIKUCHI, Atsushi TAKEDA

Clinical Pharmacology and Therapy：Vol.20 No.6　2010

Clinical efficacy of Watanebe Active Oyster on sperm profiles in healthy male subjects.

Mitsugu

Progress in Medicine： Vol.29 No.3　2009

Zinc supplementary and anti-oxidative effects of Oyster extract-containing diet in patients with Type 2 diabetes mellitus

Mitsugu WATANABE, Tetsuro YAMAMOTO, and Hideyo YAMAGUCHI

Progress in Medicine： Vol.29 No.2　2009

Beneficial effect of Oyster extract-containing diet in patients with recurrent aphthous stomatitis

Mitsugu WATANABE, Tetsuro YAMAMOTO, Ichiro SAITO, Hideyo YAMAGUCHI